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. 2021 Oct 21;224(12):2010–2019. doi: 10.1093/infdis/jiab543

Figure 1.

Figure 1.

Adaptive immune responses to SARS-CoV-2 viral components at 12 months PSO. A, SARS-CoV-2–specific CD4 and CD8 T-cell responses were detected at 12 months PSO by expression of IFN-γ upon peptide stimulation and intracellular cytokine staining. B, Antibodies to SARS-CoV-2 nucleocapsid protein at 12 months postinfection. Threshold shows the global MFI of antibodies to endemic hCoVs using the same sera in the same assay. C, Frequency of CD4 T-cell responses to the tested viral components N, M, and S in all patient groups. D, Frequency of CD8 T-cell responses to the tested viral components N, M, and S in all patient groups. Bars represent the median value in each group. P values in the plots indicate the significance by Mann-Whitney test. Abbreviations: CMV, cytomegalovirus; hCoV, human coronavirus; IFN-γ, interferon-γ; IP, inpatient; M, membrane; MFI, mean fluorescence intensity; N, nucleocapsid; O2, oxygen supplementation; OP, outpatient; PSO, post symptoms onset; S, spike; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.