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. 2021 Oct 21;224(12):2010–2019. doi: 10.1093/infdis/jiab543

Figure 3.

Figure 3.

Polyfunctionality, cytotoxicity, and activation of SARS-CoV-2–specific CD4 or CD8 T cells. A, Polyfunctionality of CD4 T-cell responses to SARS-CoV-2N protein measured by IL-2 and IFN-γ. B, Cytotoxicity of IFN-γ+ CD8 T cells to SARS-CoV-2N protein measured by expression of intracellular granzyme B and membrane CD107a. C, Frequencies of CD69 and PD-1 in SARS-CoV-2 N-specific IFN-γ+ CD4 T cells in each patient group. Gray symbols in the inpatient group represent inpatients without oxygen supplementation. D, A representative flow plot of cytotoxic CD8 T cells by the expression of granzyme B and CD107a. Abbreviations: GrB, granzyme B; IFN-γ, interferon-γ; IL, interleukin; IP, inpatient; O2, oxygen supplementation; OP, outpatient; P, patient; PD-1, programmed cell death protein 1; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.