FIGURE 1.

Dementia correlates with APN deficiency. (a) Original axial T1‐weighted MRI revealed medial temporal atrophy, including the hippocampus and frontotemporal cortex. (b) The level of APN in plasma of dementia patients and cognitively normal controls. (c) Correlation between APN concentration and CDR in each diagnostic group. (d) Correlation between APN concentration and MMSE in each diagnostic group. (e) The level of APN in plasma of 2/6‐month‐old 5xFAD mice and the controls. (f) The relative expression of APP, BACE1, ADAM10, and IDE in the hippocampus region. (g) Quantification of Aβ plaque in the hippocampus, cortex, and amygdala region of 5xFAD and 5xFAD*APN KO mice. Data were expressed as mean ± SEM, ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001