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. 2021 Nov 14;20(12):e13514. doi: 10.1111/acel.13514

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© 2021 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Proteome profiling overview of brain hippocampus in WT, 5xFAD, and 5xFAD*APN KO mice. Principal component analysis (PCA) and partial least squares‐discriminate analysis (PLS‐DA) of total proteins identified. (b) The expression patterns of cluster 3 and cluster 5. (c, f) The Venn diagram analysis between DEPs and cluster 3/5. (d, g) KEGG pathway analysis of 631 DEPs in cluster 3 and 256 DEPs in cluster 5. (e, h) The DEPs cluster 3 and 5 involved in the essential pathways were visualized by hierarchical heatmap clustering