FIGURE 6.

AR promoted Aβ clearance by increasing lysosome activity in microglia. The effect of AR on Aβ accumulation in primary microglia from the brain of APN KO mice. (b) The effect of APN deficiency on the phagocytosis of primary microglia from the WT and APN KO mice. (c‐d) The relative expression of LAMP1 and CTSD in primary microglia from the WT and APN KO mice. (e‐g) The relative expression of LAMP1 and CTSD in primary microglia from the APN KO mice with or without inhibitor treatment. (h) The relative expression of LAMP1, LAMP2, CTSD, and CTSB when the expression abundance of microglia was used as the baseline according to the results from mass spectrometry. Data were expressed as mean ± SEM, ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001