FIGURE 3.

Chronic treatment of SR12343 reduces cellular senescence in liver of Ercc1 ^{−/ Δ} mice. (a) Liver sections of treated or untreated Ercc1 ^{−/ Δ} mice were stained SA‐β‐gal activity. Ten random fields at 10× magnification were captured and data were presented as the average of the absolute number of SA‐β‐gal⁺ cells. (b) RT‐qPCR analysis of liver tissues of Ercc1 ^{−/ Δ} mice was performed to evaluate the expression of senescent markers and SASP factors. Error bars indicate SEM. n = 5 per group. (c) Western blots showing expression of p‐p65/p65, p16, p21, Pai‐1, and COX2 in the liver of Ercc1 ^{−/ Δ} mice treated with vehicle or SR12343. n = 5 per group