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. 2021 Dec 15;9(3):e00615-21. doi: 10.1128/spectrum.00615-21

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Copyright © 2021 Cao et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — Altered bacterial microbiota biodiversity in TB patients. The α-diversity of the bacterial microbiota at the genus level based on (A) observed richness and (B) the Simpson index. PCoA analysis based on (C) unweighted UniFrac distance and (D) weighted UniFrac distance. The dissimilarity was analyzed using Adonis tests with 999 permutations. R^2 value (effect size) which means the percentage of the variation explained by the grouping, as well as P value to determine the statistical significance were shown in the figures. Global composition of bacterial microbiota at the (E) phylum and (F) genus levels. Only the top 10 taxa were presented in the graph. HS, healthy subjects; Naive TB, naive TB patients; TB2MT, TB patients after 2 months of treatment; TB6MT, TB patients after 6 months of treatment. (Wilcoxon Rank Sum test, *, P < 0.05; **, P < 0.01; ***, P < 0.001).