FIG 1.
Characterization of blaIMP-4 and blaNDM-1-coharboring plasmid pKOX7525_1. (A) Plasmid structure of pKOX7525_1. (B) Schematic illustration comparing the structural features of plasmid pKOX7525_1 with sequences of plasmid pA (CP068445). Gray shading and squares indicate homologies between the corresponding genetic loci on each plasmid. Arrows indicate open reading frames, with arrowheads indicating the direction of transcription: red, antibiotic resistance-encoding genes; black, individual conjugation-related genes; blue, transposon- and integron-associated genes; green, replication-associated genes; other genes are shown by white arrows. (C) The possible formation route from pA to pKOX7525_1.