TABLE 1.
Phenotypic and genotypic characteristics of strains used in our studya
| Name | Phenotype of AST (MICs, μg/mL) |
Genotype of carbapenem-resistance | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAZ | FEP | TZPb | CZA | IMP | MEM | ATMb | CIP | LEVb | AMK | TGC | COL | ||
| K. michiganensis strain 7525 | >128 | >128 | >256 | >128 | >128 | 64 | >256 | 64 | 16 | 2 | 0.125 | 0.25 | blaIMP-4, blaNDM-1 |
| E. coli J53 (pKOX7525_1) | >128 | >128 | >256 | >128 | >128 | 64 | 6 | 2 | 1 | 2 | 0.125 | 0.25 | blaIMP-4, blaNDM-1 |
| XH2065 | >128 | >128 | >256 | >128 | >128 | 64 | 4 | 2 | 0.5 | 4 | 0.125 | 0.25 | blaIMP-4, blaNDM-1 |
| XH2066 | >128 | >128 | 4 | 128 | 32 | 8 | 8 | 4 | 0.5 | 8 | 0.125 | 0.25 | bla IMP-4 |
| XH2067 | >128 | >128 | 4 | 128 | 32 | 16 | 6 | 2 | 0.5 | 2 | 0.125 | 0.25 | bla IMP-4 |
| XH2068 | ≤0.125 | ≤0.125 | 0.5 | 0.125 | 0.5 | ≤0.125 | 0.094 | ≤0.125 | 0.016 | 2 | 0.125 | 0.25 | ND |
| E. coli J53 | ≤0.125 | ≤0.125 | 0.5 | 0.125 | 0.5 | ≤0.125 | 0.125 | ≤0.125 | 0.016 | 2 | 0.125 | 0.25 | ND |
a
CAZ, ceftazidime; FEP, cefepime; TZP, piperacillin-tazobactam; CZA, ceftazidime-avibactam; IMP, imipenem; MEM, meropenem; ATM, aztreonam; CIP, ciprofloxacin; LEV, levofloxacin; AMK, amikacin; TGC, tigecycline; COL, colistin.
b
MIC values were determined by Etest. ND, not detected.