FIG 7.

Efficacy of pyrvinium/ciprofloxacin combination in a neutropenic murine (BALB/c female, age: 6–7 weeks, weight: 20 g) thigh infection model; single-dose (subcutaneous; 4 h after infection, 4 mice per group) treatment with ciprofloxacin, pyrvinium alone, and in combination against S. aureus SA-1199B; for drug-treated animals, CFU/thigh was determined at 24 h after infection. For controls, CFU/thigh was estimated at 4 h and 24 h after infection. The CFU/thigh is plotted as individual points, and error bars represent the SD within an experimental group.