Table III.
Variable Nplacebo/Ntelmisartan | Observed Values, Mean (SD) | Adjusted Mean Change (SE) From Baselinea | ||||||
---|---|---|---|---|---|---|---|---|
Placebo | Telmisartan | |||||||
Baseline | Final | Baseline | Final | Placebo | Telmisartan | Δb | P Value | |
SI(Clamp), mg/kg min per μU/mLc | ||||||||
Low‐dose insulin (60 mU/m2/min) (14/12) | 0.0671 (0.0472) | 0.0672 (0.0453) | 0.0631 (0.0426) | 0.0563 (0.0315) | 0.0011 (0.00886) | −0.0073 (0.01014) | −0.0084 | .5304 |
High‐dose insulin (120 mU/m2/min) (14/12) | 0.0544 (0.0470) | 0.0507 (0.0290) | 0.0456 (0.0200) | 0.0482 (0.0207) | −0.0010 (0.00646) | −0.0017 (0.00750) | −0.0007 | .9467 |
GDR, mg/kg mind | ||||||||
Low‐dose insulin (60 mU/m2/min) (14/13) | 4.23 (2.04) | 4.69 (1.98) | 4.75 (2.73) | 4.61 (1.89) | 0.39 (0.351) | 0.04 (0.376) | −0.35 | .4977 |
High‐dose insulin (120 mU/m2/min) (14/13) | 6.75 (3.48) | 7.60 (2.31) | 7.72 (3.16) | 8.18 (2.09) | 0.60 (0.425) | 0.69 (0.453) | 0.10 | .8774 |
Abbreviations: GDR, glucose disposal rate; SD, standard deviation; SE, standard error of the mean; SI, sensitivity index. aModel including main effects of treatment and center with baseline as a covariate. bTelmisartan group minus placebo group. cResults from PP dataset. dResults from FAS.