Fig. 2.

d-mannose treatment decreases infiltrating MΦ/activated Mg and increases M2-like MΦ/Mg in spinal cord of EAE mice. Flow cytometry gating and representative plots for (A) d-mannose–treated mice and (B) PBS-control mice. Gating strategies are shown for identification of the respective leukocyte subsets and are used for all samples. (C) d-mannose–treated mice have significantly fewer infiltrating MΦ/activated Mg and (D) more resident Mg than those in PBS-control mice. (E) d-mannose–treated mice have more M2-like MΦ/Mg than that of PBS-control mice. (F) d-mannose–treated mice have fewer M1-like MΦ/Mg than that of PBS-control mice. *P < 0.05, **P < 0.01, ****P < 0.0001.