Table III.

 Summary of Hung AVE Test Results for the Co‐primary End Points

Ambulatory BP Monitoring	Variable	Hung AVE Test Statistica	P Value
Diastolic BP, mm Hg	24‐hour mean	−0.41499	>.05 (NS)b
	Trough (20–24 hours)	−0.00485	Not applicablec

Abbreviation: BP, blood pressure. ^aTests an average of the minimum gains (in response) for the 9 combination cells over the corresponding monotherapies. ^bThe nonsignificant (NS) P value implies that it was not possible to detect a fixed‐dose combination, which was more efficacious than both its monotherapy components as initial therapy in the treatment of hypertension. ^c P value was not suitable for inference because the previous P value for 24‐hour mean was NS.