Table IV.
Change from Baseline in 24‐Hour Mean BP and Trough (20–24 hours) BP Measured by 24‐Hour ABPM (Efficacy Population With Last‐Observation‐Carried‐Forward)
| Treatment Group, No. | No.a | 24‐H Mean SBP/DBP by 24‐H ABPM | Trough SBP/DBP by 24‐H ABPM | ||
|---|---|---|---|---|---|
| Baseline, mean ± SD | Model‐Adjusted Change,b mean ± SE | Baseline, mean ± SD | Model‐Adjusted Change,b mean ± SE | ||
| Lis 10 | 29/29 | 145.6±11.1/93.9±5.1 | −7.5±2.1/−7.7±2.5 | 143.9±14.0/93.1±7.4 | −4.0±1.4/−4.2±1.7 |
| Lis 20 | 30/29 | 146.1±11.9/90.6±6.0 | −11.8±2.2/−7.6±2.6 | 140.0±11.9/88.3±7.2 | −7.4±1.4/−6.1±1.7 |
| Lis 40 | 38/38 | 147.6±11.4/93.4±6.6 | −10.3±1.9/−9.5±2.2 | 143.3±14.4/91.2±8.1 | −7.3±1.2/−8.1±1.5 |
| Carv CR 20 | 27/27 | 149.3±9.3/94.4±5.4 | −7.7±2.4/−1.7±2.8 | 146.9±13.2/94.9±9.0 | −5.5±1.5/−2.4±1.9 |
| Carv CR 40 | 34/34 | 146.8±10.6/93.4±6.4 | −9.8±2.0/−7.7±2.4 | 145.2±14.0/92.8±8.4 | −8.0±1.3/−7.0±1.6 |
| Carv CR 80 | 33/33 | 147.5±9.5/91.9±5.5 | −9.8±2.0/−4.4±2.5 | 145.5±15.4/91.4±10.1 | −6.3±1.3/−4.4±1.6 |
| Carv CR 20/Lis 10 | 35/33 | 143.6±10.4/92.4±6.0 | −13.5±2.0/−8.7±2.4 | 137.6±12.8/89.5±9.0 | −9.6±1.3/−6.0±1.6 |
| Carv CR 20/Lis 20 | 37/35 | 145.0±10.7/92.9±4.6 | −10.4±1.9/−7.5±2.3 | 141.2±13.7/90.6±8.2 | −7.4±1.2/−5.2±1.5 |
| Carv CR 20/Lis 40 | 34/34 | 144.2±11.9/91.1±6.7 | −14.7±2.0/−9.9±2.4 | 141.2±15.1/89.1±10.3 | −10.9±1.3/−7.4±1.6 |
| Carv CR 40/Lis 10 | 32/29 | 143.6±9.1/91.0±5.6 | −12.8±2.1/−10.7±2.6 | 140.4±10.4/89.3±7.9 | −9.7±1.3/−8.2±1.7 |
| Carv CR 40/Lis 20 | 35/33 | 142.5±10.4/91.4±5.8 | −14.2±2.0/−10.2±2.4 | 139.6±13.0/90.4±8.5 | −10.4±1.3/−8.2±1.6 |
| Carv CR 40/Lis 40 | 34/33 | 145.6±9.9/91.5±6.7 | −13.1±2.0/−6.4±2.4 | 138.3±14.5/87.4±11.6 | −9.6±1.3/−5.3±1.6 |
| Carv CR 80/Lis 10 | 28/28 | 146.2±13.1/91.5±6.2 | −16.1±2.2/−9.0±2.6 | 144.0±16.4/90.4±7.8 | −11.0±1.4/−5.7±1.7 |
| Carv CR 80/Lis 20 | 33/33 | 146.5±11.0/93.6±6.7 | −14.9±2.1/−9.6±2.4 | 143.2±14.4/91.8±10.6 | −10.4±1.3/−6.2±1.6 |
| Carv CR 80/Lis 40 | 34/34 | 145.1±10.0/93.0±5.3 | −14.0±2.0/−9.0±2.4 | 142.3±12.3/92.1±7.7 | −10.5±1.3/−7.1±1.6 |
Abbreviations: ABPM, ambulatory blood pressure monitoring; BP, blood pressure; Carv CR, carvedilol extended‐release; DBP, diastolic blood pressure; Lis, lisinopril; SBP, systolic blood pressure. aNumber of patients with a value at baseline and at end point for that measure. bBased on analysis of covariance: change=baseline+center+treatment.