Table V.
Antihypertensive Medication Use at 6‐Month Follow‐Up
| Medication Use | Diabetes (n=320) | No Diabetes (n=1710) | P Value | ICC | Adjusted P Valuea |
|---|---|---|---|---|---|
| All antihypertensive drugs | |||||
| No. of drugs, mean (95% CI) | 2.26 (2.12–2.39) | 1.86 (1.82–1.92) | <.001 | 0.150 | .048 |
| Drug intensity, mean standard doses (95% CI) | 2.35 (2.17–2.54) | 1.65 (1.59–1.71) | <.001 | 0.071 | <.001 |
| Patients using specific drug classes, No. (%) | |||||
| Diuretic | 209 (65) | 1141 (67) | |||
| ACE inhibitor | 176 (55) | 589 (34) | |||
| ARB | 116 (36) | 646 (38) | |||
| CCB | 131 (41) | 463 (27) | |||
| BB | 70 (22) | 271 (16) | |||
| Drug intensityb by individual class, overall, mean (95% CI)c | |||||
| Diuretic | 0.57 (0.49–0.65) | 0.50 (0.47–0.52) | .08 | 0.058 | .35 |
| ACE inhibitor | 0.83 (0.72–0.94) | 0.42 (0.39–0.46) | <.001 | 0.087 | .002 |
| ARB | 0.39 (0.33–0.46) | 0.40 (0.37–0.42) | .93 | 0.192 | .93 |
| CCB | 0.36 (0.30–0.41) | 0.22 (0.20–0.24) | <.001 | 0.053 | .01 |
| BB | 0.18 (0.13–0.23) | 0.10 (0.09–0.11) | .005 | 0.028 | .06 |
| Drug intensityb by individual class, if prescribed, mean (95% CI) | |||||
| Diuretic | 0.87 (0.78–0.97) | 0.74 (0.71–0.78) | .01 | 0.058 | .12 |
| ACE inhibitor | 1.51 (1.37–1.65) | 1.22 (1.16–1.29) | <.001 | 0.087 | .02 |
| ARB | 1.09 (0.99–1.18) | 1.05 (1.01–1.09) | .48 | 0.192 | .73 |
| CCB | 0.87 (0.79–0.95) | 0.81 (0.76–0.85) | .16 | 0.053 | .27 |
| BB | 0.81 (0.64–0.97) | 0.64 (0.59–0.68) | .049 | 0.028 | .07 |
Abbreviations: ACE, angiotensin‐converting enzyme; ARB, angiotensin receptor blocker; BB, β‐blocker; BP, blood pressure; CCB, calcium channel blocker; CI, confidence interval; ICC, intraclass correlation coefficient. aAdjusted for clustering. bDrug intensity measured as mean standard doses. cMean of all patients including those with dose of 0.