Table I.
Hemodynamic, Hormonal, and Euglycemic Clamp Changes Associated With 6 Weeks of a High‐Fat Diet
| Week 0 | Week 1 | Week 6 | ||
|---|---|---|---|---|
| Dogs | 8 | 7 | 8 | P Value |
| Weight, kg | 22.4±0.5 (range 5.1) | 25.8±.6b (range 4.8) | 29.8±0.7c,e (range 7) | <.0001 |
| Mean arterial blood pressure, mm Hg | 89.6±2.4 (range 15.8) | 94.6±2.8a (range 20.4) | 106.4±4.1c,e (range 4.1) | .02 |
| Heart rate, beats per min | 94.2±1.9 (range 10) | 107.1±3.5b (range 14) | 114.5±3.5c,e (range 16) | <.0001 |
| Fasting insulin, pmol/L | 78.1±3.1 (range 27.7) | 112.8±2.2b (range 20.8) | 219.6±7.1c,e (range 55.6) | <.0001 |
| Glucose, mmol/L | 5.3±0.4 (range 0.6) | 5.2±0.4 (range 1.1) | 5.4±0.5 (range 1.1) | .652 |
| MPRF, mg glucose, kg of pre‐fat per wt/min | 11.4±0.2 (range 2.3) | 7.16±0.42b (range 3.21) | 4.02±0.29c,e (range 2.37) | <.0001 |
| Epinephrine, pg/mL | 230.1±24.8 (range 182) | 185.3±40 (range 276) | 147.1±28.4d (range 245) | .02 |
Values are expressed as mean ± standard error. Abbreviations: MPRF,whole body glucose uptake during a euglycemic clamp (indexed to pre‐fat diet weight); Week 0, before starting the high‐fat diet; Week 1, after 1 week of high‐fat diet; Week 6, after 6 weeks of the high‐fat diet. aSignificant difference P<.05 week 1 vs week 0. bSignificant difference P<.01 week 1 vs week 0. cSignificant difference P<.01 week 6 vs week 0. dSignificant difference P<.05 week 6 vs week 0. eSignificant difference P<.01 week 6 vs week 1.