Table II.
Changes in Norepinephrine Kinetic Variables Associated With 6 Weeks of a High‐Fat Diet
| Week 0 | Week 1 | Week 6 | ||
|---|---|---|---|---|
| Dogs | 8 | 7 | 8 | P Value |
| NE, pg/mL | 241±16 (range 154) | 254±33 (range 224) | 285±27 (range 225) | .09 |
| NECl, L/min | 1.36±0.12 (range 1.01) | 2.39±0.56 (range 4.31) | 2.52±.39a (range 2.93) | .039 |
| NEAP, μg/min | 0.396±.033 (range .307) | 0.704±.167 (range 1.279) | 0.682±.080b (range .693) | .021 |
| NE2, μg/min | 3.44±0.59 (range 4.97) | 4.87±0.80c (range 6.74) | 4.66±0.97a (range 7.73) | .009 |
| Q1, μg | 0.378±.07 (range 0.60) | 0.492±0.066 (range 0.537) | 0.539±0.07a (range 0.496) | .031 |
| Q2, μg | 103.3±20.8 (range 165.8) | 147±32.6 (range 224.9) | 107.2±17.9 (range 146.3) | .138 |
| R12, μg/min | 0.426±.047 (range .389) | 0.840±.253 (range 1.909) | 0.785±.112b (range 1.038) | .036 |
| MRC1, mL/min | 1.580±.106 (range 0.925) | 2.49±.506 (range 3.929) | 2.351±.294a (range 2.130) | .04 |
| VD1, L | 1.37±.27 (range 1.95) | 2.26±.57 (range 4.12) | 2.41±.57a (range 4.05) | .02 |
Values are expressed as mean ± standard error. Abbreviations: MRC1, norepinephrine clearance rate from the intravascular compartment; NE, plasma norepinephrine; NE2, norepinephrine release into the extravascular compartment; NEAP, noncompartmental norepinephrine appearance rate in plasma; NECl, noncompartmental norepinephrine clearance form plasma; Q1, norepinephrine mass in the intravascular compartment; Q2, norepinephrine mass in the extravascular compartment; R12, rate of norepinephrine appearance into the intravascular compartment; VD1, volume of distribution of norepinephrine in the intravascular compartment; Week 0, before starting the high‐fat diet; week 1, after 1 week of high‐fat diet; Week 6, after 6 weeks of the high‐fat diet. aSignificant difference P<.05 week 6 vs week 0. bSignificant difference P<.01 week 6 vs week 0. cSignificant difference P<.01 week 1 vs week 0.