Table III.
Logistic Regressions for CKD and CVD Based on Metabolic Components
| Variables | CKD | CVD | ||
|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |
| Metabolic components | ||||
| Dysglycemia | 1.45 (1.35–1.55) | 1.08 (1.01–1.17) | 1.79 (1.69–1.90) | 1.52 (1.43–1.62) |
| Hypertension | 2.55 (2.33–2.8) | 1.4 (1.27–1.55) | 2.10 (1.95–2.27) | 1.43 (1.32–1.55) |
| Proteinuria | 2.36 (2.16–2.59) | 2.09 (1.89–2.31) | 1.69 (1.55–1.86) | 1.52 (1.39–1.67) |
| Dyslipidemia | 1.37 (1.28–1.47) | 1.23 (1.14–1.33) | 0.941 (0.89–1.00) | 0.85 (0.8–0.91) |
| Obesity | 1.01 (0.94–1.08) | 1.29 (1.2–1.39) | 1.04 (0.98–1.10) | 1.15 (1.08–1.22) |
| Increasing components | ||||
| Control | 1 | 1 | 1 | 1 |
| One | 1.88 (1.53–2.31) | 1.05 (0.84–1.31) | 1.41 (1.22–1.64) | 0.99 (0.85–1.15) |
| Two | 2.83 (2.33–3.45) | 1.25 (2.33–3.45) | 1.85 (1.61–2.13) | 1.10 (0.95–1.27) |
| Three | 3.22 (2.64–3.92) | 1.44 (2.64–3.92) | 2.06 (1.78–2.37) | 1.22 (1.05–1.41) |
| Four | 4.41 (3.59–5.43) | 1.9 (1.52–2.37) | 2.88 (2.47–3.35) | 1.64 (1.40–1.93) |
| Five | 7.64 (5.86–9.94) | 3.65 (2.75–4.83) | 3.84 (3.07–4.80) | 2.27 (1.80–2.86) |
Values are expressed in odds ratios (95% confidence intervals). Each metabolic risk factor for either chronic kidney disease (CKD) (estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m2) or cardiovascular disease (CVD) (recorded as the composite of self‐reported MI, CABG, CHF, arrhythmia, or stroke) on crude (univariate) and adjusted (multivariate) analysis. N=24,118 after excluding missing values in age, sex, race, education and tobacco and alcohol use. On forward selection analysis, dysglycemia was the most important risk factor for CVD (highest Wald chi‐square statistic) in patients with an eGFR <60 mL/min/1.73 m2. Thereby risk components are presented in order of importance and depict increasing risk factor and collective odds for eGFR <60 mL/min/1.73 m2 and CVD.