Table.

Clinical and Laboratory Data From the Randomized Patients

Parameters	Basal	Spironolactone	Placebo
Systolic blood pressure, mm Hg	137±7.5	122±9.8^a	136±12.9
Diastolic blood pressure, mm Hg	89±3.2	82±7.5^a	86±9.2
Fasting plasma glucose, mg/dL	99±9.2	86±14.2^a	86±12.7
HOMA‐IR	3.3±2.49	2.7±1.95	2.4±1.66
LDL cholesterol, mg/dL	115±33.2	117±57.1	93±34.0
HDL cholesterol, mg/dL	41±9.1	49±12.2^a	52±18.7
Triglycerides, mg/dL	199±86.3	160±66.5^a	170±96.7
Potassium, mEq/L	4±0.1	4±0.3	4±0.3
Aldosterone, ng/dL	3.7±1.88	14.4±9.15^a	7.4±5.04
Plasma renin activity, ng/mL/h	0.8±0.42	1.2±0.50	1.0±0.50
Creatinine clearance, mL/min	171±42.5	138±38.0^a	162±53.9
Microalbuminuria, mg/24 h	6.7±4.77	11.4±7.41	22±39.30

Abbreviations: HDL, high‐density lipoprotein; HOMA‐IR, homeostasis model assessment of insulin resistance; LDL, low‐density lipoprotein. Values are expressed as mean ± SD. ^a P<.05 vs basal vs placebo.