Table II.
Quantitative Changes of MS Criteria and Different Biochemical Parameters According to the Presence of MS
N=642 | MS (n=171; 26.7%) | No MS (n=471; 73.3%) | P MS | P No MS | P MS vs No MS | |
---|---|---|---|---|---|---|
Body mass index, kg/m2 | Baseline | 28.9±3.9 | 26.2±2.9 | NS | NS | <.001 |
Study end | 28.8±3.8 | 26.3±3.0 | ||||
Waist circumference, cm | Baseline | 100.8±9.3 | 95.3±8.7 | NS | NS | .006 |
Study end | 99.4±9.3 | 95.4±9.1 | ||||
Systolic blood pressure, mm Hg | Baseline | 138.6±17.6 | 124.4±18.4 | <.001 | NS | <.001 |
Study end | 129.9±17.6 | 124.7±18.9 | ||||
Diastolic blood pressure, mm Hg | Baseline | 86.4±9.5 | 80.3±11.5 | NS | NS | <.001 |
Study end | 82.8±10.1 | 79.5±11.0 | ||||
Pulse pressure, mm Hg | Baseline | 52.2±6.3 | 44.1±5.1 | .01 | NS | <.001 |
Study end | 47.1±5.2 | 45.2±5.3 | ||||
Total cholesterol, mg/dL | Baseline | 187.4±40.1 | 182.8±42.0 | <.001 | <.001 | NS |
Study end | 167.7±34.6 | 166.7±30.8 | ||||
LDL cholesterol, mg/dL | Baseline | 119.4±35.5 | 116.0±35.6 | <.001 | <.001 | NS |
Study end | 99.5±25.1 | 99.1±25.5 | ||||
NEFA, mg/dL | Baseline | 213.8±69.3 | 148.1±50.4 | NS | NS | <.001 |
Study end | 201.6±93.3 | 152.5±57.0 | ||||
HDL cholesterol, mg/dL | Baseline | 35.6±8.7 | 43.7±12 | <.001 | <.001 | <.001 |
Study end | 38.5±9.4 | 45.3±12.2 | ||||
VLDL cholesterol, mg/dL | Baseline | 32.7±26.8 | 22.6±19.9 | <.001 | <.001 | <.001 |
Study end | 27.7±18.7 | 21.4±11.4 | ||||
Triglycerides, mg/dL | Baseline | 176.8±90.9 | 111.9±46.1 | <.001 | NS | <.001 |
Study end | 149.9±73.2 | 107.7±44.6 | ||||
Apolipoprotein B, mg/dL | Baseline | 107.4±26.6 | 93.7±26.2 | <.001 | <.001 | <.001 |
Study end | 97.0±27.1 | 87.0±29.9 | ||||
TG/HDL cholesterol | Baseline | 5.3±3.5 | 2.8±1.6 | <.001 | NS | <.001 |
Study end | 4.3±3.2 | 2.6±1.6 | ||||
Fasting glucose, mg/dL | Baseline | 125.6±37.0 | 102.9±22.6 | <.001 | NS | <.001 |
Study end | 120.1±42.2 | 103.2±19.5 | ||||
HbA1c, % | Baseline | 7.7±2.4 | 5.6±0.3 | NS | NS | .025 |
Study end | 7.7±2.7 | 5.6±0.4 | ||||
HOMA index | Baseline | 4.9±2.9 | 2.9±1.9 | .05 | NS | .059 |
Study end | 3.9±3.1 | 3.1±2.8 |
Abbreviations: HbA1c, glycated hemoglobin A1c; HDL, high‐density lipoprotein; HOMA, homeostasis model assessment; LDL, low‐density lipoprotein; MS, metabolic syndrome; NEFA, nonesterified fatty acid; NS, not significant; P MS, P value between baseline and study end in patients with MS; P MS vs No MS, P value between baseline values in patients with and without MS; P No MS, P value between baseline and study end in patients without MS; TG, triglycerides; VLDL, very low‐density lipoprotein.