FIGURE 4.

Plexin‐B family and HERC2 play critical roles in cervical cancer drug resistance. (A and B) Viability of SiHa with PLXNB1 siRNA after cisplatin treatment (A) and paclitaxel treatment (B); p‐value for SiHa‐PLXNB1 siRNA‐1 are marked: *p < .05, **p < .01. (C and D) Viability of SiHa cells with HERC2 siRNA after cisplatin treatment (C) and paclitaxel treatment (D); p‐value for SiHa‐HERC2 siRNA‐3 are marked: *p < .05, **p < .01. (E) Schematic diagram of plexin‐B family‐related drug‐resistant pathways. Genes whose odds ratio > 1 are marked by a red pie circle, and drug‐screening results are represented by colour blocks. Blue block indicates gene was positively selected in HeLa cells while purple block in SiHa cells. Mutation frequencies are marked beside gene names