. 2021 Nov 23;84(3):1039–1055. doi: 10.3233/JAD-215085

Table 1.

Baseline determinants of the Ln[brain atrophy rate] –placebo group

Variable (n = 68–81)	Pearson correlation^# (n = 68–81)		Multiple regression^*
			Model 1		Model 2		Model 3		Model 4		Model 5		Model 6
	β	p	β	p	β	p	β	p	β	p	β	p	β	p
LnFe_1	0.28	0.011	0.26	0.025	0.29	0.010	0.24	0.038					0.41	0.009
			0.28	0.012 ^†			0.36^‡	0.003 ^‡
LnCys_1	0.30	0.004	0.28	0.050	0.37	0.004			0.18	0.144			0.25	0.088
			0.29	0.042 ^†					0.29^‡	0.013 ^‡
LntHcy_1	0.41	0.000	0.19	0.208			0.33	0.013	0.27	0.052	0.37	0.003	0.22	0.161
			0.22	0.194^†					0.30	0.042 ^†
LnSi_1	0.15	0.116											–0.26	0.140
LnAl_1	–0.05	0.352											–0.01	0.942
LnAs_1	–0.08	0.249											–0.11	0.353
LnCu_1	0.00	0.485											–0.10	0.400
LnBrain_Volume_1	–0.24	0.014	–0.27	0.055	–0.34	0.009		NS		NS		NS	–0.26	0.073
			0.050 ^†
Age	0.23	0.021		NS		NS		NS		NS		NS		NS
Sex	0.12	0.153		NS		NS		NS		NS		NS		NS
			F = 4.9,		F = 5.5,		F = 4.9,		F = 3.3,		F = 4.3,		F = 3.3,
			p = 0.000,		p = 0.000,		p = 0.001,		p = 0.006,		p = 0.003,		p = 0.002,
			Adjusted		Adjusted		Adjusted		Adjusted		Adjusted		Adjusted
			R² = 0.26		R² = 0.25		R² = 0.22;		R² = 0.15;		R² = 0.14		R² = 0.25
							0.14^‡		0.12^‡

^*Adjusted for LnBrain_Volume_1, age, and sex. NS, not significant; _1, baseline. ^†Additionally adjusted for creatinine_1, and taurine_1. ^#One-sided T-test. ^‡Model w/o tHcy.