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. 2021 Nov 23;84(3):1039–1055. doi: 10.3233/JAD-215085

Table 2.

Association of cognition at the end of study with serum iron, tHcy, and Cys at baseline –Pearson correlation*

Baseline variable (n = 92–97) Semantic memory Visuospatial episodic memory Verbal episodic memory Attention/processing speed
LnGraded_Naming_2 LnPal_Totter_2 LnHVLT-TR_2 LnHVLT-DR_2 LnSDMT_2 LnMap_Search_2 LnTrail_Making_A_2
β p β p β p β p β p β p β p
Placebo group
LnFe_1 –0.17 0.049 0.18 0.041 –0.15 0.072 –0.18 0.045
LnAl_1 –0.19 0.037 0.18 0.044 0.21 0.026 –0.20 0.027
LnHcy_1 –0.33 0.000 0.10 0.156 –0.36 0.000 –0.37 0.000 –0.31 0.000 –0.39 0.000 0.38 0.000
LnCys_1 –0.22 0.009 0.19 0.027 –0.23 0.009 –0.14 0.081 0.21 0.012
B vitamin group
LnFe_1 0.07 0.241 0.06 0.280 –0.07 0.251 –0.06 0.298
LnAl_1 –0.06 0.282 0.02 0.426 –0.01 0.457 0.03 0.395
LnHcy_1 0.09 0.189 –0.04 0.333 0.03 0.366 0.07 0.236 –0.21 0.013 0.07 0.246 0.01 0.459
LnCys_1 0.09 0.189 –0.23 0.008 0.00 0.489 –0.02 0.415 –0.02 0.431

*Ln, natural logarithm; _1, baseline; _2, end of study; one-sided T-test. Empty β and P cells indicate no correlation. Note: higher Pal_Totter_2 and Trail_Making_A_2 scores indicate worse cognitive performance.