. 2021 Nov 23;84(3):1039–1055. doi: 10.3233/JAD-215085

Table 3.

Determinants of global cognition at the end of study: LnMMSE_2, placebo group^*

Variable (n = 82–112)	Pearson correlation		Multiple regression^#
			Model 1		Model 2		Model 3		Model 4		Model 5		Model 6
	β	p	β	p	β	p	β	p	β	p	β	p	β	p
LntHcy-_1	–0.28	0.003	–0.38	0.011	–0.33	0.031	–0.31	0.038	–0.29	0.050	–0.41	0.010
LnCys_1	–0.19	0.048
LnFe_1	0.05	0.650	0.25	0.035			0.19	0.109	0.17	0.130	0.24	0.051	0.32	0.008
LnAl_1	0.08	0.425	–0.20	0.050	–0.13	0.192	–0.13	0.201			–0.17	0.103	–0.19	0.078
LnTG_1	0.09	0.370	–0.21	0.031	–0.19	0.057	–0.07	0.512	–0.19	0.059			–0.20	0.052
LnPhAcase_1	–0.11	0.286	–0.27	0.008	–0.33	0.002	–0.29	0.008	–0.26	0.012	–0.27	0.011
LnBrain Volume_1	0.39	0.000	0.33	0.007	0.41	0.001	0.36	0.006	0.32	0.010	0.32	0.012	0.27	0.032
Atrophy rate	–0.36	0.006	–0.25	0.027	–0.18	0.096	–0.33	0.004	–0.23	0.044	–0.27	0.018	–0.22	0.061
LnMMSE_1	0.34	0.000	0.25	0.009	0.25	0.012	0.23	0.022	0.25	0.010	0.25	0.011	0.30	0.003
Age	–0.28	0.003		NS		NS		NS		NS		NS		NS
			F = 6.3,		F = 6.0,		F = 5.6,		F = 6.2,		F = 6.0,		F = 5.5,
			p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,
			Adjusted		Adjusted		Adjusted		Adjusted		Adjusted		Adjusted
			R² = 0.50		R² = 0.47		R² = 0.45		R² = 0.47		R² = 0.46		R² = 0.44

^*Ln, natural logarithm; PhAcase, phenylacetate hydrolase; TG, triglyceride; _1, baseline; _2, end of study; NS, not significant. ^#Adjusted for age, sex, LnCreatinine_1, and LnTaurine_1.