. 2021 Nov 23;84(3):1039–1055. doi: 10.3233/JAD-215085

Table 6.

Determinants of attention/speed at the end of study: LnTrail_Making_A_2, placebo group^*

Variable (n = 82–112)	Pearson correlation		Multiple regression^#
			Model 1		Model 2		Model 3		Model 4		Model 5
	β	p	β	p	β	p	β	p	β	p	β	p
LnCys_1	0.21	0.024		NS		NS		NS		NS		NS
LntHcy_1	0.38	0.000	0.25	0.051	0.24	0.039	0.25	0.042	0.27	0.033	0.26	0.043
			0.24^$	0.083^$
LnFe_1^∧	–0.08	0.457	–0.23	0.026			–0.18	0.086
			–0.22^$	0.041 ^$
LnSi_1^∧	–0.02	0.852							–0.18	0.077	–0.21	0.043
LnPhAcase_1	0.14	0.163					0.21	0.036	0.23	0.022
LnBrain Volume_1	–0.40	0.000	–0.04^$	0.771^$
Atrophy rate	0.34	0.002	0.28	0.012	0.18	0.067	0.32	0.005	0.28	0.012	0.23	0.040
LnTrail_Making_A_1	0.52	0.000	0.31	0.002	0.35	0.000	0.33	0.001	0.35	0.000	0.34	0.001
Age	0.37	0.000	0.28	0.015	0.19	0.073	0.29	0.011	0.32	0.006	0.31	0.009
			F = 9.6,		F = 8.8,		F = 8.9,		F = 9.3,		F = 9.1,
			p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,
			Adjusted		Adjusted		Adjusted		Adjusted		Adjusted
			R² = 0.44		R² = 0.46		R² = 0.50		R² = 0.48		R² = 0.47

^*Ln, natural logarithm; _1, baseline; _2, end of study; NS, not significant. ^#Adjusted for LnCys_1 and sex. ^∧ Fe and Si were not significant when present in models together. ^$Model with LnBrain Volume_1. Note: Trail_Making_A_2 score indicates worse cognitive performance.