. 2021 Nov 23;84(3):1039–1055. doi: 10.3233/JAD-215085

Table 7.

Determinants of attention/speed at the end of study: LnTrail_Making_B_2, placebo group^*

Variable (n = 82–112)	Pearson correlation		Multiple regression^#
			Model 1		Model 2		Model 3		Model 4
	β	p	β	p	β	p	β	p	β	p
LntHcy_1	0.21	0.033	0.08	0.389	0.11	0.277	0.11	0.256	0.08	0.439
LnFe_1^∧	–0.10	0.342	–0.21	0.016			–0.13	0.225	–0.08	0.459
			–0.11^$	0.246^$
LnSi_1^∧	–0.04	0.727			–0.23	0.014	–0.15	0.181	–0.09	0.399
					–0.18^$	0.082^$
LnAl_1	–0.03	0.759	0.18	0.039	0.19	0.036	0.21	0.022
			0.19^$	0.049 ^$	0.23^$	0.023 ^$
LnBrain Volume_1	–0.37	0.001	–0.17^$	0.110^$	–0.16^$	0.137^$
LnAtrophy_rate	0.11	0.327
Trail_Making_B_1	0.66	0.000	0.66	0.000	0.67	0.000	0.67	0.000	0.62	0.000
Age	0.30	0.002		NS		NS		NS		NS
			F = 12.0,		F = 10.4,		F = 10.8,		F = 12.8,
			p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,
			Adjusted		Adjusted		Adjusted		Adjusted
			R² = 0.46,		R² = 0.46,		R² = 0.46		R² = 0.44
			0.55^$		0.56^$

^*Ln, natural logarithm; _1, baseline; _2, end of study: NS, not significant. ^#Adjusted for LntHcy_1, LnCys_1, age, and sex. ^$Models with LnBrain_Volume_1. ^∧ Not significant in models w/o Al. Note: Trail_Making_B_2 score indicates worse cognitive performance.