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. 2021 Nov 9;10(4):423–434. doi: 10.3233/JHD-210482

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© 2021 – The authors. Published by IOS Press

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — OVT73 have more significant metabolite-metabolite correlations than controls. The ggcorrplot() function in R was applied to GC-MS metabolomics dataset (Ref. data 4), producing correlation coefficients, p-values and visual plots, as shown, for every variable-variable pair, with comparison of OVT73 and control groups. Significantly positively correlated metabolites are displayed as red squares and significantly negatively correlated metabolites are displayed as blue squares (p < 0.05) according to the figure legend. As shown by the number of coloured squares, there were more significantly correlated metabolite-metabolite pairs in the OVT73 cerebellum (B) and liver (D) compared to their respective control plots; control cerebellum (A) and control liver (C).