TABLE 10.
Comparison of “best” European immunoblot interpretation rule with best rule for individual laboratories
| Laboratory | Strain | European rule no. | European rule | % Sens/% spec for European rulea | Individual laboratory rule | % Sens/% spec for individual laboratory rulea |
|---|---|---|---|---|---|---|
| A | ACA1 | 5 | 3 bands from p41 (M)b, OspC (M), p83/100, p39, p41, p17 | 80/94 | 19 alone or 2 bands from p58, OspC (M), p41 (M) | 80/92 |
| B | ESP1 | 2 | 2 bands from p41 (M), OspC (M), p83/100, p58, p39 | 81/94 | 2 bands from p39, OspC, OspC (M), p21 | 85/98 |
| C | A395 | 6 | 3 bands fsrom p41 (M), OspC (M), p83/100, p39, p17, OspC | 56/99 | 2 bands from p34, OspC(M), p21, p41 | 73/97 |
| D | PKo | 7 | 2 bands from p41 (M), OspC (M), p83/100, p39, p41, p17, OspC | 83/92 | p41 and p43, or p58, or p14, or OspC(M) | 83/95 |
| D | PBi | 5 | 2 bands from p41 (M), OspC (M), p83/100, p39, p41, p17 | 74/89 | p58, or OspC (M), or p21, or p30 | 79/93 |
| E | VS461 | 4 | 3 bands from p41 (M), OspC (M), p83/100, p39, p17 | 67/97 | 3 bands from p58, p39, p28, p83/100, p41 (M), p60 (M) | 78/96 |
| F | Ne83 | 6 | 3 bands from p41 (M), OspC (M), p83/100, p39, p17, OspC | 78/87 | 3 bands from p43, p54/55, p41, OspC (M), p41 (M) | 80/96 |
a
Sens, sensitivity; spec, specificity. Sensitivity calculated by combining data for patient with EM and LB. Specificity was calculated by combining data for potential cross-reactor and healthy individuals' sera.
b
M, IgM.