Table 1. Effect of actG on the cariogenicity of S. mutans in rats (Keyes’ score).
| Infecting strain | Buccal | Sulcal | Proximal | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| E | Ds | Dm | DX | E | Ds | Dm | DX | E | Ds | Dm | DX | ||
| UA159 pDL278 | 18.7 ± 3.5 | 8.8 ± 3.3 | 6.2 ± 2.1 | 3.3 ± 1.2 | 19.7 ± 2.9 | 15.3 ± 2.7 | 8.8 ± 2.6 | 3.5 ± 1.4 | 5.0 ± 0.9 | 3.3 ± 0.5 | 2.2 ± 0.8 | 0.0 | |
| UA159 pDL278-actG | 7.7 ± 2.1a | 3.7 ± 1.6b | 2.7 ± 1.0d | 0.0d | 10.0 ± 2.4a | 5.3 ± 1.2a | 3.3 ± 1.2b | 0.0d | 3.0 ± 0.9a | 1.7 ± 0.5a | 0.0a | 0.0 | |
Results are presented as mean ± SD (n = 6; a P < 0.0001, b P < 0.001, c P < 0.01, or d P < 0.05).
E: enamel only.
Ds: slight dentinal (1/4 of the dentin between the enamel and pulp chamber affected).
Dm: moderate dentinal (between 1/4 and 3/4 of the dentin affected).
Dx: extensive dentinal (beyond 3/4 of the dentin affected).