Summary of findings 2. Summary of findings table ‐ Psychological treatment 1 compared to psychological treatment 2 for depression in patients with coronary artery disease.

Psychological treatment 1 compared to psychological treatment 2 for depression in patients with coronary artery disease
Patient or population: health problem or population Setting: cardiology outpatient settings Intervention: Psychological Treatment 1 Comparison: Psychological Treatment 2
Outcomes	Anticipated absolute effects* (95% CI)		Relative effect (95% CI)	№ of participants (studies)	Certainty of the evidence (GRADE)	Comments
	Risk with Psychological Treatment 2	Risk with Psychological Treatment 1
Depression symptoms ‐ short term (end of treatment) assessed with: objective and self‐reported measures of depression symptoms; higher scores indicate more severe symptoms	Not pooled	Not pooled	Not pooled	219 (3 RCTs)	‐	No meta‐analysis performed due to clinical heterogeneity. The evidence is very uncertain as to whether different psychological interventions may result in a reduction in depression symptoms at the end of treatment for: cognitive‐behavioural therapy compared to supportive stress management (Freedland 2009); behaviour therapy compared to person‐centred therapy (Brown 1993); cognitive‐behavioural therapy and well‐being therapy compared to clinical management (TREATED‐ACS 2020).
Depression remission ‐ short term (end of treatment) assessed with: below cut‐off on Hamilton Rating Scale for Depression	571 per 1000	707 per 1000 (493 to 857)	OR 1.81 (0.73 to 4.50)	83 (1 RCT)	⊕⊕⊝⊝ Lowa	There is low certainty evidence from one trial that cognitive‐behavioural therapy may result in no difference in depression remission at the end of treatment compared to supportive stress management (Freedland 2009).
All‐cause mortality ‐ short term (end of treatment) ‐ not reported	‐	‐	‐	‐	‐	No data for all‐cause mortality at end of treatment in trials comparing psychological intervention versus another psychological intervention/clinical management
Cardiovascular mortality ‐ short term (end of treatment) ‐ not reported	‐	‐	‐	‐	‐	No data for cardiovascular mortality at end of treatment in trials comparing psychological intervention versus another psychological intervention/clinical management
Myocardial infarction ‐ short term (end of treatment) ‐ not reported	‐	‐	‐	‐	‐	No data for the occurrence of myocardial infarction at end of treatment in trials comparing psychological intervention versus another psychological intervention/clinical management
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; OR: odds ratio
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.
See interactive version of this table: https://gdt.gradepro.org/presentations/#/isof/isof_question_revman_web_427665509108780589.

^a Imprecision rated down two levels ‐ wide confidence intervals from one trial encompass an adverse effect to beneficial effect