1. Overview of study population.
| Study ID | Intervention | [n]screened | [n] randomised | [n] ITT | [n] finishing study | [%] of randomised participants finishing study | Comments |
| Abbasi 2015 | Intervention 1 (I1): simvastatin Intervention 2 (I2): atorvastatin |
Total: 206 | I1: 29 I2: 29 Total: 58 |
I1: NR I2: NR Total: NR (per‐protocol) |
I1: 23 I2: 23 Total: 46 |
I1: 79.3% I2: 79.3% Total: 79.3% |
|
| ANDROS 2015 | Intervention (I): sertraline Control (C): placebo |
Total: ? | I: ? C: ? Total: 2 |
I: ? C: ? Total: ? |
I: ? C: ? Total: ? |
I: ? C: ? Total: ? |
Comment: trial terminated early, no results posted |
| Barth 2005 | Intervention (I): resource‐orientated psychotherapy Control (C): usual care |
Total: 1709 | I: 27 C: 32 Total: 59 |
I: 27 C: 32 Total: 59 (per‐protocol) |
I: 27 C: 28 Total: 55 |
I: 100% C: 87.5% Total: 93.2% |
|
| Brown 1993 | Intervention 1 (I1): behaviour therapy Intervention 2 (I2): person‐centred therapy |
Total: 107 | I1: NR I2: NR Total: 54 |
I1: NR I2: NR Total: NR (per‐protocol) |
I1: 20 I2: 20 Total: 40 |
I1: ? I2: ? Total: 74.1% |
Comment: dropout reported in text, no flow chart |
| CREATE 2007 | Intervention 1 (I1): interpersonal psychotherapy, citalopram, clinical management Intervention 2 (I2): citalopram, clinical management Control 1 (C1): interpersonal psychotherapy, placebo, clinical management Control 2 (C2): placebo, clinical management |
Total: 1897 | I1: 67 I2: 75 C1: 75 C2: 67 Total: 284 |
I1: 67 I2: 75 C1: 75 C2: 67 Total: 284 |
I1: 59 I2: 72 C1: 59 C2: 47 Total: 237 |
I1: 88.1% I2: 96.0% C1: 78.7% C2: 70.1% Total: 83.5% |
Comment: 2 x 2 factorial trial; only I2 and C2 data are eligible for this review |
| Carney 2009 | Intervention 1 (I1): sertraline plus omega‐3 Intervention 2 (I2): sertraline plus placebo |
Total: 941 | I1: 62 I2: 60 Total: 122 |
I1: 62 I2: 60 Total: 122 |
I1: 59 I2: 56 Total: 115 |
I1: 95.2% I2: 93.3% Total: 94.3% |
|
| Dao 2011 | Intervention (I): cognitive‐ behavioural therapy C: usual care |
Total: 513 | I: 50 C: 50 Total: 100 |
I: NR C: NR Total: NR (per‐protocol) |
I: 48 C: 48: Total: 96 |
I: 96% C: 96% Total: 96% |
|
| Divsalar 2018 | Intervention 1 (I1): sertraline plus red yeast rice Intervention 2 (I2): sertraline plus placebo |
Total: 101 | I1: 28 I2: 28 Total: 56 |
I1: NR I2: NR Total: NR |
I1: 25 I2: 25 Total: 50 |
I1: 89.3% I2: 89.3% Total: 89.3% |
|
| Doering 2007 | Intervention (I): cognitive‐ behavioural therapy Control (C): usual care |
Total: 117 | I: NR C: NR Total: NR |
I: NR C: NR Total: NR (per‐protocol) |
I: 7 C: 8 Total: 15 |
I: ? C: ? Total: ? |
Comment: reasons for dropout not stated, no flow chart Comment: nested trial within observational study (non‐depressed cohort) |
| EsDEPACS 2014 | Intervention (I): escitalopram Control (C): placebo |
Total: 4809 | I:149 C: 151 Total: 300 |
I: 108 C: 109 Total: 217 (per‐protocol) |
I: 78 C: 79 Total: 157 |
I: 52.3% C: 52.3% Total: 52.3% |
Comment: nested trial within observational study (depressed cohort receiving usual care) |
| ENRICHD 2003 | Intervention (I): cognitive‐ behavioural therapy Control (C): usual care |
Total: 33780 | I: 1238 C: 1243 Total: 2481 |
I: 1238 C: 1243 Total: 2481 |
I: 983 C: 985 Total: 1968 |
I: 79.4% C: 79.2% Total: 79.3% |
|
| Fang 2003 | Intervention (I): health education and psychological intervention Control (C): usual care |
Total: ? | I: 27 C: 30 Total: 57 |
I: ? C: ? Total: ? |
I: ? C: ? Total: ? |
I: ? C: ? Total: ? |
Comment: translated paper |
| Freedland 2009 | Intervention 1 (I1): cognitive‐ behavioural therapy Intervention 2 (I2): supportive stress management Control (C): usual care |
Total: 2955 | I1: 41 I2: 42 C1: 40 Total: 123 |
I1: 41 I2: 42 C1: 40 Total: 123 |
I1: 40 I2: 33 C1: ? Total: ? |
I1: 98% I2: 79% C1: ? Total: ? |
|
| Freeman 1986 | Intervention (I): alprazolam Control (C): placebo |
Total: 459 | I: 54 C: 53 Total: 107 |
I: NR C: NR Total: NR (per‐protocol) |
I: 32 C: 28 Total: 60 |
I: 59.3% C: 52.8% Total: 56.1% |
Comment: no flow chart |
| Kennedy 2005 | Intervention (I): escitalopram Control (C): placebo |
Total: NR | I: 9 C: 10 Total: 19 |
I: NR C: NR Total: NR (per‐protocol) |
I: 2 C: 2 Total: 4 |
I: 22.2% C: 20.0% Total: 21.1% |
Comment: trial terminated early, redacted results posted |
| Li 2005 | Intervention (I): St John's wort extract Control (C): placebo |
Total: ? | I: ? C: ? Total: 87 |
I: ? C: ? Total: ? |
I: 43 C: 39 Total: 82 |
I: ? C: ? Total: 94.3% |
Comment: translated paper |
| Liu 1999 | Intervention (I): fluoxetine Control (C): placebo |
Total: ? | I: ? C: ? Total: ? |
I: ? C: ? Total: ? |
I: 31 C: 37 Total: ? |
I: ? C: ? Total: ? |
Comment: translated paper |
| Liu 2016 | Intervention 1 (I1): sertraline and Shugan Jieyu Intervention 2 (I2): sertraline and placebo |
Total: 3907 | I1: 76 I2: 73 Total: 149 |
I1: 76 I2: 73 Total: 149 |
I1: 48 I2: 46 Total: 94 |
I1: 63.2% I2: 63.0% Total: 63.1% |
Comment: no flow chart, reasons for dropout reported in text |
| MIND‐IT 2007 | Intervention (I): mirtazapine Control (C): placebo |
Total: 2177 | I: 47 C: 44 Total: 91 |
I: 47 C: 44 Total: 91 |
I: 22 C: 18 Total: 40 |
I: 46.8% C: 40.9% Total: 44.0% |
Comment: nested trial within observational study (depressed cohort receiving usual care) |
| Ma 2019 | Intervention (I): Xinkeshu Control (C): placebo |
Total: 312 | I: 30 C: 30 Total: 60 |
I: NR C: NR Total: NR |
I: 28 C: 27 Total: 55 |
I: 93.3% C: 90% Total: 91.7% |
|
| McFarlane 2001 | Intervention (I): sertraline Control (C): placebo |
Total: 238 | I: 18 C: 20 Total: 38 |
I: NR C: NR Total: NR (per‐protocol) |
I: 12 C: 15 Total: 27 |
I: 66.7% C: 75.0% Total: 71.1% |
Comment: no flow chart, reasons for dropout reported in text |
| McLaughlin 2005 | Intervention (I1): telephone counselling Control (C): usual care |
Total: 700 | I: 53 C: 47 Total: 100 |
I: NR C: NR Total: NR (per‐protocol) |
I: 45 C: 34 Total: 79 |
I: 84.9% C: 72.3% Total: 79% |
|
| MoodCare 2011 | Intervention (I): cognitive‐ behavioural therapy Control (C): usual care | Total: 3071 | I: 61 C: 60 Total: 121 |
I: NR C: NR Total: NR |
I: 53 C: 53 Total: 106 |
I: 86.9% C: 88.3% Total: 87.6% |
|
| Pizzi 2009 | Intervention (I): sertraline Control (C): placebo |
Total: 630 | I: 50 C: 50 Total: 100 |
I: NR C: NR Total: NR (per‐protocol) |
I: 47 C: 48 Total: 95 |
I: 94% C: 96% Total: 95% |
|
| Roose 1998 | Intervention 1 (I1): paroxetine Intervention 2 (I2): nortriptyline |
Total: NR | I1: 41 I2: 40 Total: 81 |
I1: 41 I2: 40 Total: 81 |
I1: 37 I2: 30 Total: 67 |
I1: 90.2% I2: 75.0% Total: 82.7% |
Comment: no flow chart, reasons for dropout reported in text |
| SADHART 2002 | Intervention (I): sertraline Control (C): placebo |
Total: 11546 | I: 186 C: 183 Total: 369 |
I: 186 C: 183 Total: 169 |
I: 133 C: 137 Total: 270 |
I: 71.5% C: 74.9% Total: 73.1% |
|
| SPIRR‐CAD 2011 | Intervention (I): stepwise psychotherapy intervention Control (C): usual care |
Total: 21780 | I: 285 C: 285 Total: 570 |
I: 284 C: 284 Total: 568 |
I: 110 C: 194 Total: 304 |
I: 38.6% C: 68.1% Total: 53.3% |
|
| Shahmansouri 2014 | Intervention 1 (I1): fluoxetine Intervention 2 (I2): Crocus sativus L. (saffron) |
Total: 75 | I1: 22 I2: 22 Total: 44 |
I1: NR I2: NR Total: NR (per‐protocol) |
I1: 20 I2: 20 Total: 40 |
I1: 90.9% I2: 90.9% Total: 90.9% |
|
| Strik 2000 | Intervention (I): fluoxetine Control (C): placebo |
Total: 556 | I: 27 C: 27 Total: 54 |
I: 27 C: 27 Total: 54 |
I: 22 C: 18 Total: 40 |
I: 81.5% C: 66.7% Total: 74.1% |
|
| Tian 2016 | Intervention 1 (I1): paroxetine Intervention 2 (I2): fluoxetine |
Total: ? | I1: 23 I2: 23 Total: 46 |
I1: 23 I2: 23 Total: 46 (per‐protocol) |
I1: 23 I2: 23 Total: 46 |
I1: 100% I2: 100% Total: 100% |
Comment: no flow chart was reported. It is unclear whether 16 participants who did not finish the study were from I1 or I2 groups, or non‐treatment or non‐depressed groups. |
| TREATED‐ACS 2020 | Intervention 1 (I1): cognitive‐behavioural therapy and well‐being therapy Intervention 2 (I2): clinical management |
Total: 740 | I1: 50 I2: 50 Total: 100 |
I1: 50 I2: 50 Total: 100 |
I1: 42 I2: 40 Total: 82 |
I1: 84% I2: 80% Total: 82% |
|
| U‐CARE 2018 | Intervention (I): internet cognitive‐behavioural therapy Control (C): usual care |
Total: 3928 | I: 117 C: 122 Total: 239 |
I: 117 C: 122 Total: 239 |
I: 96 C: 115 Total: 211 |
I: 82.1% C: 94.3% Total: 88.3% |
|
| UPBEAT 2012 | Intervention 1 (I1): sertraline Intervention 2 (I2): exercise Control (C): placebo |
Total: 1680 | I1: 40 I2: 37 C: 24 Total: 101 |
I1: NR I2: NR C: NR Total: NR |
I1: 36 I2: 36 C: 23 Total: 95 |
I1: 90% I2: 97.3% C: 95.8% Total: 94.1% |
Comment: only I1 sertraline and C placebo are eligible for this review |
| Wang 2020 | Intervention 1 (I1): escitalopram Intervention 2 (I2): Bu Xin Qi decoction |
Total: 300 | I1: 140 I2: 140 Total: 280 |
I1: NR I2: NR Total: NR (per‐protocol) |
I1: 113 I2: 115 Total: 228 |
I1: 80.7% I2: 82.1% Total: 81.4% |
Comment: reasons for dropout not stated in flow chart |
| WIDeCAD 2017 | Intervention (I): internet cognitive‐behavioural therapy Control (C): wait‐list control |
Total: 72 | I: 18 C: 16 Total: 34 |
I: 18 C: 16 Total: 34 |
I: 13 C: 13 Total: 26 |
I: 72.2% C: 81.3% Total: 76.5% |
|
| Yang 2019 | Intervention (I): intensive telephone‐based care Control (C): usual care |
Total: 354 | I: 112 C: 112 Total: 224 |
I: NR C: NR Total: NR |
I: 107 C: 105 Total: 212 |
I: 95.5% C: 93.8% Total: 94.6% |
|
| Zarea 2014 | Intervention (I): Peplau's therapeutic communication model Control (C): usual care |
Total: ? | I: ? C: ? Total: ? |
I: ? C: ? Total: ? (per‐protocol) |
I: 37 C: 37 Total: 74 |
I: ? C: ? Total: ? |
Comment: total sample estimated from degrees of freedom in Table 3 |
ITT = intention‐to‐treat; NR = not reported; ? = unclear