Sourizahi 2017.

Study name	Comparison of therapeutic effect of sertraline and supportive psychotherapy in comparison with placebo in coronary heart disease patients with mild to moderate depression
Methods	RCT design: 2‐arm parallel‐group trial Total N randomised: 90 Length of follow‐up: no follow‐up Analysis: not specified
Participants	Location: Iran Number of study centres and setting: not specified. Investigators are affiliated with Zahedan University of Medical Sciences. CAD criteria: coronary heart disease, not further specified Depression criteria: patients mild or moderate depression who fulfill ICD criteria for any: F32 Depressive episode, F32.0 Mild depressive episode, or F32.1 Moderate depressive episode Other entry criteria: no serious medical illness, no use of psychiatric drugs Exclusion criteria: heart medications affecting the mood
Interventions	Intervention: sertraline 50 mg/d with weekly dose 150 to 200 mg per week, plus supportive supportive psychotherapy consisting of: discussion about depression in response to the diagnosis of heart disease, controlled diaphragmatic breathing and gradual muscle relaxation training, exposure and cognitive therapy, behavioural activation, pleasant activity scheduling Control: sertraline placebo (vitamin C)
Outcomes	Depression level measured by the HAM‐D
Starting date	22 December 2017
Contact information	Mohammadislam Sourizahi Zahedan University of Medical Sciences Zahedan, Dr Hesabi square 9816743463 Zahedan Iran (Islamic Republic of) T: +98 54 3329 5715 E: dr.sourizahi58@zaums.ac.ir
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