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. 2021 Oct 22;28(1):126–138. doi: 10.1111/cns.13746

FIGURE 4.

FIGURE 4

Effects of GAIP interacting protein, C terminus 1 (GIPC1) overexpression on seizure susceptibility and local field potential (LFP) in KA‐induced epileptic mice. (A) Schematic diagram of the experimental design. (B−D) Statistical graphs of the latency period (B), the total number of SRSs (C), and the proportion of stage 4−5 SRSs over the total number of SRSs (D), showing that overexpression of GIPC1 prolonged the latency, decreased the number of SRSs, and alleviated the seizure severity in the GIPC1 + KA group compared with that in the KA and Con‐GIPC1 + KA groups, respectively (n = 10 in the KA group, n = 9 in the Con‐GIPC1 + KA group, and n = 11 in the GIPC1 group). (E) Representative LFP images. (F, G) Statistical analyses indicating that both the number of SLEs (F) and the duration of SLEs (G) were decreased in the GIPC1 + KA group compared with that in the other two groups (n = 5 per group). *p < 0.05 and ***p < 0.001