FIGURE 6.

The functional prediction of gut microbiota based on KEGG and COG database in HG group. (A) The PICRUSt analysis based on KEGG database used to predict microbial metabolic function and analyze the functional differences. Mean proportion and their differences in predicted function of the gut microbiota between HG and NG group. (B) Study of functional group protein families based on COG databases between HG group and NG group. (C) LEfSe analysis was performed between the HG group and NG group to identify the differences of functional prediction based on KEGG database. Only the taxa meeting a significant LDA threshold value of >2.0 are shown. (D) Distinct COG pathways identified in the HG group and NG group using LEfSe analysis. Only the taxa meeting a significant LDA threshold value of >2.0 are shown [Colour figure can be viewed at wileyonlinelibrary.com]