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. 2021 Dec 14;97(24):e2404–e2413. doi: 10.1212/WNL.0000000000012945

Figure 2. NfL Levels of Manifest SCA2 and Controls in Group A and Receiver Operating Characteristic Curves for Discrimination.

Figure 2

(A and C) Neurofilament light (NfL) levels in CSF and matched serum were significantly higher in individuals with manifest spinocerebellar ataxia type 2 (SCA2) than in controls. NfL levels are shown by boxplots with Tukey whiskers. (B and D) Residual NfL levels in CSF and matched serum were significantly higher in those with manifest SCA2 than in controls. Residuals were generated from the regression of CSF NfL or serum NfL on age representing the component of CSF NfL or serum NfL not explained by age. Residual NfL levels are shown by boxplots with Tukey whiskers. (E) Very high degree of consistency was identified between CSF and serum NfL levels. (F) Area under a receiver operating characteristic curve (AUC) gives a measure of the discriminatory ability of a test; 0.8 indicates an 80% probability of the test giving correct answer, and 1 indicates a 100% probability. CSF NfL had essentially perfect accuracy to distinguish between those with manifest SCA2 and controls. In addition, serum NfL exhibited excellent accuracy. NfL values were natural log-transformed for statistical analyses and are displayed geometrically.