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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: J Thorac Cardiovasc Surg. 2020 Jan 11;161(6):e485–e498. doi: 10.1016/j.jtcvs.2019.12.075

Central Picture.

Central Picture

Inhaled NO reduced microglial activation induced by DHCA in hippocampus.

Central Message: DHCA induces microglial activation and neuronal degeneration. Inhaled NO after DHCA may reduce neuronal degeneration by ameliorating neuroinflammation in the hippocampus.