FIGURE 4.

Simulation of the drug effect profile accounting for variability between patients (median black line surrounded by the 90% confidence interval shaded area) under the currently approved dosing regimen (squared light‐gray area) and after doubling the concentrations. The typical values of E_max,M2 (28.6 ms) and EC_50,M2 (855 ng/mL) for the final model are shown by the horizontal and vertical black dashed lines, respectively. E_max,M2, maximal M2 effect; EC_50,M2, M2 concentration needed to achieve 50% of E_max,M2