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. 2021 Oct 14;27(12):2127–2135. doi: 10.1038/s41591-021-01548-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — (a) Adjusted effects of vaccine type and months since second vaccination on probability of belonging to the low Ct sub-population; (b) adjusted effects of vaccine type and months since second vaccination on Ct values within the low Ct sub-population; (c) adjusted effects of calendar time on Ct values within the low Ct sub-population. Shaded areas represent 95% confidence intervals. Note: data include all new PCR positives among those ≥18 years old; estimated at the reference category for other factors (27 April 2021, male, no previous PCR/antibody-positive, not reporting a long-term health condition). In (c), test for non-linearity in effect of calendar date p = 0.003 for low and <0.0001 for high Ct sub-population (two-sided Wald test without adjustment for multiple comparison).