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. 2021 Oct 14;600(7889):506–511. doi: 10.1038/s41586-021-04069-y

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Maps and dates of national and regional restrictions in England. Second national lockdown: closed hospitality businesses; contacts ≤ 2, outdoors only; open schools; reasonable excuse needed for leaving home⁴⁵. Tier 1: private indoor gatherings of ≤6 persons. Tier 2: as tier 1 plus restricted hospitality services; gatherings of ≤6 in public outdoor places. Tier 3: as tier 2 plus most hospitality businesses closed. Tier 4: as tier 3 but single outdoor contact. Third national lockdown: closed schools with the exception of key workers. b, Local lineage-specific R_t values for Alpha and the average R_t value (growth per 5.1 d) of all of the other lineages in the same periods. c, R_t values from n = 315 LTLA shown in b. The box centre horizontal line indicates the median, box limits show the quartiles, the whiskers extend to 1.5× the interquartile range. d, Total and lineage-specific incidence (top) and R_t values (bottom) for six selected LTLAs during the period of restrictions. e, Crude lineage-specific fold changes (odds ratios) in Alpha and other lineages across the second (orange) and third national lockdown (red).

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