FIG. 10.

CSB gene disruption increases UV-induced apoptosis rate in p53^−/− MEFs. MEFs of the indicated genotypes were subjected to UVC radiation (5 or 10 J/m²) and assayed for apoptosis 24 h later via flow cytometry (% sub-G₁) as described in Materials and Methods. The histogram represents data obtained from two independent experiments (P < 0.05 for p53^−/− versus CSB^−/− p53^−/− after irradiation with both 5 and 10 J/m²).