Fig. 3. Iteration of model across site and orientation.

To understand how placement and orientation of the TMS coil might impact symptoms, we computed our model across multiple sites and orientations. Sites were defined at equally spaced points along the anterior to posterior axis of the middle frontal gyrus. Roll and pitch were defined orthogonal to the scalp at each stimulation site. Multiple equally spaced yaw vectors were defined at each stimulation site, representing all possible coil orientations. Electric (e)-field models were conducted at each site/orientation combination, entered into our symptom prediction model, and the results were plotted in this site × orientation heatmap.