Table 2.

Associations between polygenic risk for Late-onset Alzheimer’s disease (LOAD-PGR) and MRI volumetric measures.

	Partially adjusted				Fully adjusted
	Polygenic risk for LOAD		PGR*APOE e4		Polygenic risk LOAD		PGR*APOE e4
	β	p	β	p	β	p	β	p
Left hippocampal volume	−0.146	0.002	−0.148	0.802	−0.118	0.002	−0.111	0.363
Right hippocampal volume	−0.128	0.026	−0.116	0.846	−0.071	0.099	−0.234	0.560
Whole brain volume	−0.055	0.201	−0.074	0.439	−0.049	0.075	−0.089	0.615
White matter volume	−0.058	0.351	−0.054	0.911	−0.022	0.115	−0.015	0.138
Log white matter hyperintensity volume	0.026	0.054	0.034	0.002	0.007	0.549	0.062	0.972
Grey matter volume	−0.173	0.393	−0.017	0.960	−0.051	0.904	−0.074	0.430

β = standardised betas reflecting per standard deviation increased polygenic risk (PGR), and per APOE e4 allele. Bold = significant p < 0.05. Models are partially adjusted for age, BMI, sex, genotyping chip, 8 genetic principal components and fully adjusted for additional smoking, APOE e4 dose and social deprivation.