Table 3.

Associations between polygenic risk for Late-onset Alzheimer’s disease (LOAD-PGR) and hippocampal subdivisions.

	Partially adjusted				Fully adjusted
	Polygenic risk LOAD		PGR*APOE e4		Polygenic risk LOAD		PGR*APOE e4
	β	p	β	p	β	p	β	p
Left Hippocampal head	−0.036	0.003	−0.030	0.367	−0.014	0.017	−0.013	0.075
Left Hippocampal body	−0.056	0.002	−0.032	0.167	−0.069	0.002	−0.051	0.295
Left Hippocampal tail	−0.071	0.167	−0.013	0.075	−0.027	0.016	0.026	0.918
Right Hippocampal head	−0.046	0.023	−0.098	0.679	−0.017	0.044	−0.092	0.563
Right Hippocampal body	−0.029	0.063	−0.023	0.810	−0.031	0.074	−0.041	0.126
Right Hippocampal tail	−0.043	0.935	−0.029	0.809	−0.095	0.932	−0.040	0.113

β = standardised betas reflecting per standard deviation increased polygenic risk (PGR), and per APOE e4 allele. Bold = significant p < 0.05. Models are partially adjusted for age, BMI, sex, genotyping chip, 8 genetic principal components and fully adjusted for additional smoking, APOE e4 dose and social deprivation.