Table 4.

Associations between polygenic risk for Late-onset Alzheimer’s disease (LOAD-PGR) and cognitive function.

	Partially adjusted				Fully adjusted
	Polygenic risk LOAD		PGR*APOE e4		Polygenic risk LOAD		PGR*APOE e4
	β	p	β	p	β	p	β	p
Fluid intelligence	−0.066	5 × 10−6	−0.101	0.705	−0.080	0.002	−0.165	0.769
Matrix completion	−0.073	7 × 10−5	−0.216	0.499	−0.102	0.003	0.057	0.393
Numerical memory	−0.232	0.043	−0.011	0.966	−0.039	0.178	−0.054	0.924
Reaction time	0.022	0.003	0.053	0.701	0.014	0.226	0.048	0.186
Trail making	−0.073	2 × 10−6	−0.013	0.068	−0.026	0.112	0.027	0.404
Symbol digit	−0.114	0.001	−0.013	0.876	−0.038	0.090	−0.025	0.885

β = standardised betas reflecting per standard deviation increase in polygenic risk and per APOE e4 allele increase. Bold = significant p < 0.05. Models are partially adjusted for age, BMI, sex, genotyping chip, 8 genetic principal components and fully adjusted for additional smoking, APOE e4 dose and social deprivation.