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. 2021 Dec 15;11:24022. doi: 10.1038/s41598-021-03432-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Two molecular subtypes of HCC were identified by NMF clustering. (A) Consensus map for NMF Clustering. (B) When rank = 2–10, the cophenetic correlation, residual sum of squares (RSS) and silhouette distribution. (C) Survival curves of C1 and C2 subtypes in TCGA dataset. (D) PFS of C1 and C2 subtypes in the TCGA cohort. E: Heat map of expression of 84 HRD genes in subtypes.