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. 2021 Dec 15;11:24022. doi: 10.1038/s41598-021-03432-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The pathway enrichment analysis of DEGS and subtypes. (A) Go functional annotation of differentially upregulated genes, including top 10 biological process (BP), top10 cellular component (CC) and top 10 molecular function (MF). (B) KEGG annotation of differentially upregulated genes. (C) GO functional annotation of differentially down-regulated genes. (D) KEGG annotation results of differentially regulated genes. E: GSEA analysis of main enriched pathways in the C1(left) and C2(right).