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. 2021 Dec 15;11:24022. doi: 10.1038/s41598-021-03432-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The prognostic model was validated in separate cohorts. (A) Risk score distribution, existential state, and 4 gene expression heat maps of HCC cases in the GSE14520 cohort. (B) The survival analysis of patients in different risk groups in the GSE14520 validated cohort. (C) 1-year, 3-year, and 5-year ROC curves in the GSE14520 cohort based on the 4-gene scoring model. (D) Risk score distribution, existential state and heat map of 4 genes in HCC patients in the HCCDB18 dataset. (E) The 4-gene scoring model was used to evaluate the OS of the samples in the HCCDB18 dataset. (F) 1-year, 3-year, and 5-year ROC curves for HCC patients in the HCCDB18 data sets.