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. 2021 Dec 15;12:7293. doi: 10.1038/s41467-021-27488-x

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

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Fig. 8 — a–d Schematic of CFH(Y/Y)-RPE (a, c) and CFH(H/H)-iRPE (b, d) following CI-HS (a, b) or CC-HS (c, d) treatments. Under basal (CI-HS) conditions, CFH(H/H)-iRPE show higher tendency for sub-RPE deposits as compared to CFH(Y/Y)-iRPE, likely because of increased alternate complement activation around RPE cells (a, b). Enhanced activation of human complement (CC-HS) further exaggerates AMD cellular phenotypes in iRPE cells; CFH(H/H)-iRPE show predisposition to disease as compared to CFH(Y/Y)-iRPE (c, d).