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. 2021 Dec 15;12:7308. doi: 10.1038/s41467-021-27077-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a SE analysis of H3K27ac ChIP-seq data in VCaP cells cultured in regular medium. b H3K27ac signal fold change of all 1244 SEs under vehicle condition versus 2 h or 24 DHT stimulation. (c) Combined H3K27ac HiChIP and H3K27ac, 4C-seq, 3C-ddPCR, AR, and CTCF ChIP-seq annotation showing confident interactions anchored at MYC promoter. For H3K27ac interactions, loops with less than 10 mated reads were filtered out. The 4C-seq and HiChIP results showed DHT stimulation attenuated the looping from MYC promoter to the left arm (PCAT1-SEs (#1, #2, and #3)) but enhanced the looping from MYC promoter to the right arm (ABS-#1, ABS-#2, and ABS-#3). For 3C-ddPCR, the MYC-promoter was used as bait (constant) that is paired with primers specifically located in target regions.