Table 1.
Demographic, clinical, and imaging characteristics.
| Total sample | Controls | LLD | Statistics | |
|---|---|---|---|---|
| n = 109 | n = 65 | n = 44 | ||
| M, SD or % (N) | M, SD or % (N) | M, SD or % (N) | (t, χ2) | |
| Age, y | 72.07 ± 6.5 | 72.38 ± 6.3 | 71.61 ± 7.01 | t = 0.602 |
| Gender (Female) | 62.4% (68) | 60% (39) | 65.9% (29) | χ2 = 0.39 |
| Education, y | 16 ± 2.7 | 16.6 ± 2.28 | 15.1 ± 3 | t = 2.9* |
| HAM-D (24 item) | 10.35 ± 11.4 | 1.28 ± 1.3 | 23.75 ± 4.1 | t = −35.2* |
| MADRS | 11.03 ± 12.52 | 1.1 ± 1.4 | 25.75 ± 4.4 | t = −36.5* |
| Dementia Rating Scale | 139.43 ± 4.8 | 139.75 ± 4.9 | 138.95 ± 4.6 | t = 0.40 |
| Vascular Risk Measure | 0.82 ± 0.93 | 0.71 ± 0.82 | 1.0 ± 1.06 | t = −1.6 |
| Normalized WMH volume (% ICV) | 0.19 ± 0.28 | 0.15 ± 0.23 | 0.27 ± 0.33 | t = −1.68 |
| Mean FA | 0.37 ± 0.02 | 0.37 ± 0.02 | 0.37 ± 0.02 | t = 1.23 |
| PSMD 10−4 mm2/s | 3.52 ± 0.67 | 3.4 ± 0.55 | 3.64 ± 0.83 | t = −1.29 |
Vascular Risk Measure refers to a self-reported clinical measure of vascular illness.
HAM-D Hamilton Depression Rating Scale, FA fractional anisotropy, ICV intracranial volume, MADRS Montgomery–Asberg Depression Rating Scale, PSMD peak width of skeletonized mean diffusivity, WMH white matter hyperintensities
*p < 0.05.